Magnetic investigations of human mesencephalic neuromelanin
نویسندگان
چکیده
منابع مشابه
Magnetic and Structural Investigations of Nanocrystalline Cobalt-Ferrite
Cobalt ferrite is an important magnetic material due to their large magneto-crystalline anisotropy, high cohercivity, moderate saturation magnetization and chemical stability.In this study, cobalt ferrites Nanoparticles have been synthesized by the co-precipitation method and a new microemulsion route. We examined the cation occupancy in the spinel structure based on the “Rietveld with energies...
متن کامل"Subcellular proteomics" of neuromelanin granules isolated from the human brain.
"Subcellular proteomics" is currently the most effective approach to characterize subcellular compartments. Based on the powerful combination of subcellular fractionation and protein identification by LC-MS/MS we were able for the first time to 1) isolate intact neuromelanin granules from the human brain and 2) establish the first protein profile of these granules. This compartment containing n...
متن کاملQuantitative T1, T2, and T2* Mapping and Semi-Quantitative Neuromelanin-Sensitive Magnetic Resonance Imaging of the Human Midbrain
PURPOSE Neuromelanin is a dark pigment granule present within certain catecholamine neurons of the human brain. Here, we aimed to clarify the relationship between contrast of neuromelanin-sensitive magnetic resonance imaging (MRI) and MR relaxation times using T1, T2, and T2* mapping of the lower midbrain. METHODS The subjects were 14 healthy volunteers (11 men and 3 women, mean age 29.9 ± 6....
متن کاملNew face of neuromelanin.
The massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in Parkinson's disease has not yet been adequately explained. The characteristic feature of this brain region is the presence of neuromelanin pigment within the vulnerable neurons. We suggest that neuromelanin in the Parkinson's disease brain differs to that in the normal brain. The interac...
متن کاملHuman neuromelanin: an endogenous microglial activator for dopaminergic neuron death.
Substantial evidence indicates that neuroinflammation caused by microglial activation in substantia nigra is critical in the pathogenesis of dopaminergic neurodegeneration in Parkinson's disease (PD). Increasing data demonstrates that environmental factors such as rotenone, paraquat play pivotal roles in dopaminergic neuron death. Here, potential role and mechanism of neuromelanin (NM), a major...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2002
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(01)00099-0